ГОРЕ

проф. д-р Јасмина Димитрова-Шумковска

Image descriptionName: Jasmina Dimitrova-Shumkovska, PhD
Office Address: Institute of Biology Department of Experimental Physiology and Biochemistry Faculty of Natural Sciences & Mathematics, Skopje Univ. Ss Cyril and Methodius
Arhimedova 6, PO Box 162, 1000 Skopje, Republic of Macedonia
Phone: +389 2 3249, ext.600, 609
Fax: +389 2 3228141

E-mail address: jasminad@pmf.ukim.edu.mk

Languages: English, Croatian, Bulgarian, Serbian

Degrees:
2010 Doctorate in Biochemistry and Molecular Pharmacology, graduated 2010, Faculty of Natural Sciences and Mathematics, Ss Cyril and Methodius University, Skopje, Republic of Macedonia in collaboration with Medical Faculty, Department of Molecular Pharmacology, Technion Institute of Technology, Haifa, Israel Title of Doctoral Thesis: Oxidative stress induced in vivo by atherogenic diet and the carcinogen dimethylbenz[a]anthracene (7, 12 DMBA). Possible impact on atherosclerosis.
2002 Master of Science in Biology, field Biochemistry, graduated 2002, Faculty of Natural Sciences and Mathematics, Ss Cyril and Methodius University, Skopje, Republic of Macedonia Title of Master thesis: The Impact of Dietary Unsaturates and L-Arginine Administration upon Lipoprotein Metabolism in Mildly Hypercholesterolemic Wistar-Rats. Skopje (in Macedonian)
1995 Bachelor of Science in Experimental Biology, graduated 1995, Faculty of Natural Sciences and Mathematics, Ss Cyril and Methodius University, Skopje, Republic of Macedonia;

Professional Experience:
Teaching Experience as Assistant Teacher:
Practical courses form General Biochemistry since 1997 – 2009 (Institute of Biology, Faculty of Natural Sciences and Mathematics);
Medicinal Biochemistry since 1998 – current (Institute of Biology, Faculty of Natural Sciences and Mathematics);
Animal Biochemistry since 2000 – 2009 (Institute of Biology, Faculty of Natural Sciences and Mathematics);
Selected subjects in Biochemistry since 2000 – 2009 (Institute of Biology, Faculty of Natural Sciences and Mathematics)
Teaching Experience as Assistant Professor:
2010 – present Biochemistry 1 (Institute of Biology, Faculty of Natural Sciences and Mathematics)
2010 – present Biochemistry 2 (Institute of Biology, Faculty of Natural Sciences and Mathematics)
Researcher, Department of Pharmacology, Medical Faculty - Technion, Technion - Israel Institute of Technology, Haifa, Israel, Prof. M. Gavish (2006 – 2009).

Reviewer of international scientific journal:
Current Medicinal Chemistry (4.63 Impact factor for 2010)

Research interests:
1. Cholesterol metabolism
2. Atherosclerosis
3. Apo E (-/-) KO mice
4. Polycyclic aromatic hydrocarbons (vascular irritants, xenobiotic metabolism)
5. 18 kDa mitochondrial translocator protein (TSPO, formerly known as peripheral benzodiazepine receptor)
6. Markers of oxidative injury
7. Antioxidant potential of plant extracts

Professional affiliations:
Society of the Macedonian Biologists (1998- present)
Macedonian Society for Medical Biochemistry (2004- present)
Israel Society for Neurosciences (2008- present)

Invited departmental seminars:
Tема: Oxidative stress and expression of the 18 kDa translocator protein induced in vivo by atherogenic diet and the carcinogen dimethylbenz[α]anthracene (7, 12 DMBA) in liver and aorta. Studies in rat and apoe deficient mice. Implications for atherosclerosis.
Време. 15.12.2008- 18.12.2008, Department of Molecular Pharmacology, Medical Faculty, Technion, Haifa, Israel, Prof. Moshe Gavish (December, 2008)

Invited Lectures (2011):
 The 18 kDa Mitochondrial Translocator Protein Binding Density (TSPO) in Aorta of High Fat, High Cholesterol Fed Rats and Cholesterol Supplemented ApoE Deficient Mice, on the 1st Annual World Congress of Endobolism, Xiamen, China, January 25-28, 2011. http://www.lifesciences.com/wce.2011/symposium_3.asp
 Dose-dependent effects of polycyclic aromatic hydrocarbons on the mitochondrial 18 kDa translocator protein density (TSPO) in steroidogenic organs and antioxidant enzymes in a rat model of induced carcinogenesis, on the Final Workshop: Pre-Clinical Testing of Active Substances on Cancer and Various Model Systems (activity on the CPCTAS FP7 Project), Kragujevac, Serbia, March 12-17, 2011.

Selected publications in peer reviewed journals (2008- ):
Dimitrova-Shumkovska, J., Veenman, L., Ristoski, T., Leschiner, S., Gavish, M.(2010) Decreases in binding capacity of the mitochondrial 18 kda translocator protein accompany oxidative stress and pathological signs in rat liver after DMBA exposure. Toxicol Pathol; 38 (6):957-68.
Dimitrova-Shumkovska, J., Veenman, L., Ristoski, T., Leschiner, S., Gavish, M. (2010) Dimethylbenz [α] anthracene induces oxidative stress and reduces the binding capacity of the mitochondrial 18-kDa translocator protein in rat aorta. Drug Chem Toxicol; 33(4):337-47.
Dimitrova-Shumkovska J, Veenman, L., Ristoski, T., Leschiner, S., Gavish, M. (2010) Chronic high fat, high cholesterol supplementation decreases 18 kDa Translocator Protein binding capacity in association with increased oxidative stress in rat liver and aorta. Food Chem Toxicol; 48(3):910-21.
Grebenc, T., Shumkovska-Dimitrovska, J., Rusevska, K. Kraigher, H. & Karadelev, M. (2008) Molecular phylogeny and distribution of Antrodia juniperina (Murrill) Niemelä & Ryvarden and Pyrofomes demidoffii (Lév.) Kotl. & Pouzar in the Republic of Macedonia and correlation to their potential anti-cancerogenic and anti-atherogenic activities. Inter. Conference on Biology and Environ Sci, 1, 241-28.
Crceva-Nikolovska, R., Dimitrova-Shumkovska, J., Petkovska, S., Shtakleva, M., Smiljeska, V. (2008) Low beneficial effects of short term antidiabetic treatment in streptozotocin-induced dibatic rats. Biol. Macedonica, 61,151-161.
Dimitrova-Shumkovska, J., Djoshic-Markovska, B., Roganovic, D. and Anastasovska, V. (2008) 7, 12 Dimethylbenz[a]anthracene –induced protein oxidation in rat liver. Biol. Macedonica, 61, 139-149.
Dimitrova-Shumkovska, J., Djoshic-Markovska, B., Petkovska, S., Shtakleva, M., Stojanoska, S. (2008) Evaluation of oxidative stress in liver of animal model exposed to chemical carcinogen - 7, 12 dimethylbenz[a]anthracene. Bilten of XX Congress of Chemists and Technologists of Macedonia, 67-77.
Gurzanova-Durnev, Lj., Djoshic-Markovska, B., Zisovska, E., Zivkovich, J., Dimitrova-Shumkovska, J. (2008) Evaluation of erythrocyte superoxide dismutase (SOD) activity response to oxidative insult in newborn and premature infants. Biol. Macedonica, 61, 127-138.

Book Chapters:
Dimitrova-Shumkovska, J., Veenman, L., Gavish, M. (2011) the 18kDa Translocator Protein as a Potential Participant in Atheroslcerosis. In "Atherogenesis", InTech Publisher, ISBN 978-953-307-992-9 (in press).
Dimitrova-Shumkovska, J., Veenman, L., Roim, I., Gavish, M. The 18kDa Translocator Protein in mice lacking apolipoprotein E (Apo E KO -/-). In "Lipoprotein metabolism", InTech Publisher, ISBN 978-953-307-992-9 (pending).

Participation in Scientific Conferences and Congresses (2008 - ):
Dimitrova-Shumkovska, J., Veenman, L., Gavish, M. (2011) Dose-dependent effects of polycyclic aromatic hydrocarbons on the mitochondrial 18 kDa translocator protein density (TSPO) in steroidogenic organs and antioxidant enzymes in a rat model of induced carcinogenesis. CPCTAS FP7 Project, Kragujevac, p.50, Serbia (invited lecture).
Tripunoski, T., Mathe, D., Kuzmanovska, S., Ugrinska, A., Janoki, G., Balogh, L., Stojanoski, S., Vaskova, O., Blagoevska, K., Dimitrova-Shumkovska J. (2010) Evaluation of haematological radiotoxicity of rhenium-188 hydroxyethylidene diphosphonate in animal model. Days of Veterinary Medicine, Book of abstracts, p. 60-61, Ohrid, Republic of Macedonia.
Dimitrova-Shumkovska, J., Veenman, L., Leschiner, S., Gavish, M. (2010) Enhanced binding capacity of 18 kDa Translocator protein (TSPO) in platelets and erythrocytes of Apo E deficient mice. 7th International Congress of Neuroendocrinology, Rouen, France.
Dimitrova-Shumkovska, J., Ðošić-Markovska, B., Štakleva, M., Sabriu, A., Košarkoska, F., Naunovska,Е., Guržanova-Durnev, Lj. (2009) Oxidative stress in male rats fed a high fat-high cholesterol diet. Involvement of advanced oxidation protein products. Proceedings of the 17 th meeting of the Balkan Clinical Laboratory Federation, p. 77, Ohrid, Republic of Macedonia.
Dimitrova-Šumkovska, J., Veenman, L., Ðošić-Markovska, M., Ristoski, T. (2009) Impact of Cholesterol Diet on the Mitochondrial 18 kDa Translocator Protein (TSPO) in the Aorta of apoE Knockout Mice. Proceedings of the 17 th meeting of the Balkan Clinical Laboratory Federation, p. 78, Ohrid, Republic of Macedonia.
Ristoski, T., Dimitrova-Shumkovska, J., Veenman, L. (2009) Dimethylbenz[α]antracene induced hepatotoxicity and expression of the mitochondrial 18 kDa translocator protein in rat liver. 27th Meeting of the European Society of Veterinary Pathology; Krakow, Poland Book of Abstracts, p.163 published in J of Comparative Pathology.
Dimitrova Shumkovska, J., Veenman, L., Ristoski, T., Leschiner, S. and Gavish, M. (2008) The effects of high fat, high cholesterol diet on oxidative stress and expression of the 18 kDa translocator protein in rat liver and aorta. Rev Neurosc. Abstracts of the 17th Annual Meeting of the Israel Society for Neuroscience, Israel Meeting, Eilat, Israel
Grebenc, T., Shumkovska-Dimitrovska, J., Rusevska, K. Kraigher, H. & Karadelev, M. (2008) Molecular phylogeny and distribution of Antrodia juniperina (Murrill) Niemelä & Ryvarden and Pyrofomes demidoffii (Lév.) Kotl. & Pouzar in the Republic of Macedonia and correlation to their potential anti-cancerogenic and anti-atherogenic activities. Book of Abstracts, International Conference on Biological and Environmental Sciences, 26-27 September 2008, Tirana, Albania. pp 152-153.
Grebenc, T., Shumkovska-Dimitrovska, J., Rusevska, K. Kraigher, H. & Karadelev, M. (2008) Combined approach in exploring the biological activity of two fungi Antrodia juniperina and Pyrofomes demidoffii based on their phylogenetic position and relation to their anti-cancerogenic and anti-atherogenic activity. Symposium of Flora and Vegetation in Slovenia, Ljubljana. Book of Abstracts. http://bds.biologija.org/-gradiva/program-02.pdf

Participipation in Research Projects:
(2001-2004) The impact of dietary unsaturates and L-arginine administration upon lipoprotein and carbohydrate metabolism in mildly hypercholesterolemic Wistar-rats.
(2007-2008) Anticarcinogenic and antiatherogenic activity of sporocarp extract from selected taxa, typical for the region of Balcan Peninsula in correlation to the phylogenetic position of source fungi (Ministry of Science of Macedonia and Ministry of Science and Forestry of Slovenia, bilateral project);
(2007-2009) The peripheral-type benzodiazepine receptors: Cancerogenesis and Steroidogenic production: 18kDa translocator protein and oxidative stress in vivo. Horowitz Research Fund, 2000156, Elias Medical Research Fund, 2009264, Technion (Israel).
(2010-2011) Participant in the FP7 Project (CPCTAS): Centre for Pre-Clinical Testing of Active Substances sponsored by European Commission.